AustralieFrV1, Main, Exploration, bibRecord, 005E58

Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

Identifieur interne : 005E58 ( Main/Exploration ); précédent : 005E57; suivant : 005E59

Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

Auteurs : Romy Razakandrainibe [Madagascar] ; Stephane Pelleau [France] ; Georges E. Grau [Australie] ; Ronan Jambou [Madagascar]

Source :

Trends in parasitology [ 1471-4922 ] ; 2012.

RBID : Pascal:12-0179933

Descripteurs français

Pascal (Inist)
- Présentation antigène, Cellule endothéliale, Physiopathologie, Paludisme, Parasite.

English descriptors

KwdEn :
- Antigen presentation, Endothelial cell, Malaria, Parasite, Pathophysiology.

Abstract

Disruption of the endothelial cell (EC) barrier leads to pathology via edema and inflammation. During infections, pathogens are known to invade the EC barrier and modulate vascular permeability. However, ECs are semi-professional antigen-presenting cells, triggering T-cell costimulation and specific immune-cell activation. This in turn leads to the release of inflammatory mediators and the destruction of infected cells by effectors such as CD8⁺ T-cells. During malaria, transfer of parasite antigens to the EC surface is now established. At the same time, CD8 activation seems to play a major role in cerebral malaria. We summarize here some of the pathways leading to antigen presentation by ECs and address the involvement of these mechanisms in the pathophysiology of cerebral malaria.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001472
to stream PascalFrancis, to step Curation: 004A40
to stream PascalFrancis, to step Checkpoint: 001350
to stream Main, to step Merge: 006185
to stream Main, to step Curation: 005E58

Le document en format XML

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<front><div type="abstract" xml:lang="en">Disruption of the endothelial cell (EC) barrier leads to pathology via edema and inflammation. During infections, pathogens are known to invade the EC barrier and modulate vascular permeability. However, ECs are semi-professional antigen-presenting cells, triggering T-cell costimulation and specific immune-cell activation. This in turn leads to the release of inflammatory mediators and the destruction of infected cells by effectors such as CD8<sup>+</sup>
 T-cells. During malaria, transfer of parasite antigens to the EC surface is now established. At the same time, CD8 activation seems to play a major role in cerebral malaria. We summarize here some of the pathways leading to antigen presentation by ECs and address the involvement of these mechanisms in the pathophysiology of cerebral malaria.</div>
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Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri